temozolomide

[Scientific Reports] Scientists compared the efficacy of focused modulation of a set of signaling pathways in two glioblastoma cell lines, U-251 MG and T98-G, using a panel of thirteen compounds targeting cell cycle progression, proliferation, epigenetic modifications, and DNA repair mechanism.

[Molecular Cancer Research] Researchers characterized the time-dependent impact of regadenoson on brain endothelial cell interactions and paracellular transport, using mouse and rat brain endothelial cells and tumor models.

[Scientific Reports] Researchers showed here that astrocyte elevated gene-1 (AEG-1) was overexpressed in glioma tissues and associated with a worse subtype and a poor prognosis.

[Biochimica et Biophysica Acta-Reviews On Cancer] Scientists summarize different strategies that intensify the temozolomide effect such as MGMT inhibition, development of novel imidazotetrazine analog, and combination therapy; with an aim to incorporate a successful treatment and increased overall survival in glioblastoma patients.

[Acta Pharmacologica Sinica] By analyzing the hub genes of glioblastoma multiforme (GBM) via weighted gene co-expression network analysis of the cancer genome atlas dataset, and using the connectivity map platform for drug repurposing, scientists found that multiple azole compounds had potential anti-GBM activity.

[Biomed Research International] Three datasets were used to perform the analysis to search for the key genes related to glioma stem cell, temozolomide resistance, and prognosis. The key gene for further research was selected by reviewing the previous studies.