TGFβ

[Nature Reviews Cancer] The authors discuss the influence that transforming growth factor-β (TGFβ) exerts on the composition and behaviour of different cell populations present in the tumour immune microenvironment, and the context-dependent functions of this cytokine in suppressing or promoting cancer.

[Journal of Cell Science] Researchers reported the identification of 114 novel long non-coding RNAs that changed their expression during TGFβ-induced epithelial-mesenchymal transition in murine breast cancer cells.

[Scientific Reports] The authors aimed to determine a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs-like (ADAMTSL) levels in failing hearts, and to elucidate the role of ADAMTSL2 in fibrosis using cultured human cardiac fibroblasts

[Scientific Reports] Scientists demonstrated that short-term exposure to BMP7 decreased the fibrocartilage chondrocyte phenotype. The BMP7-dependent reduction of Collagen type I protein expression seemed MMP2-dependent and inhibition of Smad2/3-PAI1 activity was identified as a potential pathway via which BMP7 exerted its anti-fibrotic action.

[Cancer Letters] Scientists observed that DU145 prostate and NCI–H2228 lung cancer cells were resistant to the cytotoxic effect of rapamycin.

[Cancer Immunology Research] Researchers demonstrated that the anti-CD137 agonist urelumab can overcome TGFβ-mediated inhibition of human NK-cell proliferation and antitumor function.