The Extracellular Matrix Glycoprotein ADAMTSL2 Is Increased in Heart Failure and Inhibits TGFβ Signaling in Cardiac Fibroblasts

The authors aimed to determine a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs-like (ADAMTSL) levels in failing hearts, and to elucidate the role of ADAMTSL2 in fibrosis using cultured human cardiac fibroblasts