triple negative breast cancer

[International Journal of Molecular Sciences] Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.

[npj Breast Cancer] To determine how TNBC suppresses antitumor macrophages, scientists used microRNA-200c, a powerful repressor of epithelial-to-mesenchymal transition, to drive mesenchymal-like mouse mammary carcinoma and human TNBC cells toward a more epithelial state.

[Scientific Reports] To overcome cysteine deprivation resistance in TNBC cells, scientists identified three selective HDAC6 inhibitors using epigenetic compound library screening and used them to induce cell death in the non-mesenchymal TNBC.

[Nature Communications] Scientists found that PIK3CA-mutant ER+ breast cancers exhibited increased INPP4B mRNA and protein expression and INPP4B increased the proliferation and tumor growth of PIK3CA-mutant ER+ breast cancer cells, despite suppression of AKT signaling.

[Cell Death & Disease] Investigators provided novel insights into the mechanisms of epidermal growth factor receptor-tyrosine kinase inhibitor resistance in TNBC via interaction of IL-26 with a newly identified receptor, and suggested IL-26 as a possible therapeutic target in TNBC.

[Cancer Letters] The authors found that the gamma-aminobutyric acid type A receptor π subunit (GABRP), as a membrane protein enriched in triple-negative breast cancer stem cells, interacted with epidermal growth factor receptor (EGFR) and significantly sustained its expression, resulting in stemness maintenance and chemotherapy resistance.