triple negative breast cancer

[Molecular Oncology] The authors identified that autophagy flux was inhibited in triple-negative breast cancer (TNBC) stem cells. miRNA-181a (miR-181a) expression is upregulated both in TNBC CSCs and patient tissues.

[npj Breast Cancer] Scientists showed that reverting the high LIP/LAP ratios in TNBC cell lines into low LIP/LAP ratios by overexpression of LAP reduced migration and matrix invasion of these TNBC cells.

[Molecular Cancer Research] The authors demonstrated that MUC1-C drove global changes in chromatin architecture in the dedifferentiation of CRPC and triple-negative breast cancer cells.

[Rubius Therapeutics, Inc.] Rubius Therapeutics, Inc. announced that the first patient has been dosed in its Phase I/II clinical trial of RTX-224 for the treatment of patients with certain relapsed/refractory or locally advanced solid tumors, including non-small cell lung cancer, cutaneous melanoma, head and neck squamous cell carcinoma, urothelia carcinoma and triple-negative breast cancer.

[Cell Death & Disease] Scientists indicated that NONO enhanced nuclear epidermal growth factor receptor (EGFR)-mediated tumorigenesis and may be a potential therapeutic target for TNBC patients with nuclear EGFR expression.

[Cell Death & Disease] Knockdown of MnSOD inhibited TNBC cell invasion, breast cancer stem cells, mitochondrial reactive oxygen species, and interleukin-6 excretion promoted by multiple copies in T cell malignancy-1.