tumor associated macrophages

[ACS Nano] Researchers developed a localized drug delivery system with a step-by-step cell internalization ability based on a hierarchical-structured fiber device.

[Cancer Cell International] Researchers reported that macrophages, upon interaction with breast cancer cells, activated tumor promoting functions and exhibited differential expression of various proteins as shown by secretome analysis using proteomics studies.

[Biochemical Pharmacology] Scientists summarize what we know about tumor-associated macrophages (TAMs) and HCC, discussing the roles of TAMs in HCC development and the possible approaches for TAMs-targeted therapy as potential targets for HCC treatment.

[Cancer Immunology Immunotherapy] Large cohorts of non-small cell lung cancer patients from The Cancer Genome Atlas and a single-cell sequencing dataset were integrated to illustrate immunosuppressive phenotypes of tumor-associated macrophages, followed by experimental verification.

[International Immunopharmacology] Scientists showed that downregulation of METTL3 in prostate cancer tumor-associated macrophages modulated macrophages toward an M2-like phenotype and that this modulation was mediated by activation of STAT6.

[Aging] Investigators administrated Qi Ling (QL) to rats and collected the serum from QL-treated rats and established the co-culture system of tumor-associated macrophages/paclitaxel resistant prostate cancer cells.