tumor associated macrophages

[Biophysical Journal] The authors showed that circulating tumor cells isolated from the blood of prostate cancer patients displayed specific nanomechanical phenotypes characteristic of cell endurance and invasiveness and patient sensitivity to androgen deprivation therapy.

[Journal of Cellular and Molecular Medicine] Researchers proposed to construct an immune-related prognostic risk model based on immune-related genes MMP14 and INHBA expression that could assess the prognosis of pancreatic cancer patients and identify potential therapeutic targets for pancreatic cancer, to provide new ideas for the treatment of pancreatic cancer.

[eLife] Tumor-associated macrophages (TAMs) are abundant, and they are important mediators of disease progression and invasion. Scientists generated tumor-educated macrophages in vitro and performed detailed, multiomic characterization.

[Immunity] Researchers examined the impact of aryl hydrocarbon receptor in tumor-associated macrophage function in pancreatic ductal adenocarcinoma.

[Blood] The authors showed that late-stage Non-Hodgkin's Lymphoma was resistant to therapy targeting phagocytosis checkpoint CD47, due to the compromised capacity of tumor-associated macrophages to phagocytose lymphoma cells.

[Oncogene] Investigators showed that oral administration of propranolol delayed tumor progression of MCA205 fibrosarcoma model and MC38 colon cancer model and increased the survival rate of tumor bearing mice.