tumor associated macrophages

[Communications Biology] By analysing publicly available transcriptomic data of patient samples and cell lines, researchers identified here two specific glycan profiles in pancreatic ductal adenocarcinoma that correlated with progression, clinical outcome and epithelial to mesenchymal transition status.

[Hepatology] Scientists identified interferon regulatory factor (IRF8) as an important prognostic biomarker in hepatocellular carcinoma patients which predicted the response and sensitivity to anti-PD-1 therapy.

[Oncogene] Scientists found that the 18fluoro-deoxyglucose positron emission tomography/computed tomography-based markers were positively associated with the expression of programmed cell death ligand 1, pyruvate kinase M2, both of which indicate poor prognosis in patients with pancreatic ductal adenocarcinoma.

[Cellular Immunology] Researchers examined tumor-infiltrating lymphocytes in colorectal cancer expressing different levels of SIRT1.

[Nature Communications] Scientists performed single-cell RNA-sequencing analysis of three spinal ependymoma subtypes to dissect the microenvironmental landscape of spinal ependymomas and revealed tumor-associated macrophage subsets with distinct functional phenotypes.

[Signal Transduction and Targeted Therapy] Golgi membrane protein 1 (GOLM1) was positively correlated with infiltrating tumor-associated macrophages expressed high levels of programmed death-ligand 1 (PD-L1) and CD8+ T cell suppression in hepatocellular carcinoma tissues.