tumor initiating cells

[Scientific Reports] Researchers employed lineage-tracing to demonstrate the tumorigenicity potential of the Pten-, SOX9+ cells. They showed that these cells were capable of giving rise to mixed-lineage tumors that manifested features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CCA).

[Experimental Cell Research] The authors reported a novel role of DYRK1A in maintaining tumor growth and stemness of oral/oropharyngeal squamous cell carcinoma cells.

[JCI Insight] Investigators performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy.

[Journal of Clinical Investigation] Using hepatocellular carcinoma as a model, scientists showed that restricted glucose availability enhanced the PERK-eIF2α-ATF4 signaling axis to drive fucosyltransferase-1 (FUT1) transcription via direct binding of ATF4 to the FUT1 promoter.

[Journal of Clinical Investigation] Scientists report a regulatory mechanism involving fucosylation by which glucose restriction promoted cancer stemness to drive drug resistance and tumor recurrence.

[Journal of Cell Biology] Scientists showed that miR-146 was relevant for normal mammary stem cell and mammary cancer stem cell activity.