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Pulmonary Cell NewsScientists report a regulatory mechanism involving fucosylation by which glucose restriction promoted cancer stemness to drive drug resistance and tumor recurrence.
[Journal of Clinical Investigation]
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Loong, J. H. C., Wong, T.-L., Tong, M., Sharma, R., Zhou, L., Ng, K.-Y., Yu, H.-J., Li, C. H., Man, K., Lo, C.-M., Guan, X.-Y., Lee, T. K., Yun, J.-P., & Ma, S. K. Y. (2021). Glucose deprivation induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI143377 Cite
