ILC1 Drives Intestinal Epithelial and Matrix Remodelling

Investigators developed gut organoid cocultures with type-1 innate lymphoid cells (ILC1) to dissect the impact of their accumulation in inflamed intestines. They demonstrated that murine and human ILC1 secrete transforming growth factor β1, driving expansion of CD44v6+ epithelial crypts.
[Nature Materials]
Jowett, G. M., Norman, M. D. A., Yu, T. T. L., Rosell Arévalo, P., Hoogland, D., Lust, S. T., Read, E., Hamrud, E., Walters, N. J., Niazi, U., Chung, M. W. H., Marciano, D., Omer, O. S., Zabinski, T., Danovi, D., Lord, G. M., Hilborn, J., Evans, N. D., Dreiss, C. A., … Gentleman, E. (2020). ILC1 drive intestinal epithelial and matrix remodelling. Nature Materials, 1–10. https://doi.org/10.1038/s41563-020-0783-8 Cite
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ILC1 Drive Intestinal Epithelial and Matrix Remodelling

Investigators developed gut organoid cocultures with type-1 innate lymphoid cells (ILC1) to dissect the impact of their accumulation in inflamed intestines.
[nature materials]
Jowett, G. M., Norman, M. D. A., Yu, T. T. L., Rosell Arévalo, P., Hoogland, D., Lust, S. T., Read, E., Hamrud, E., Walters, N. J., Niazi, U., Chung, M. W. H., Marciano, D., Omer, O. S., Zabinski, T., Danovi, D., Lord, G. M., Hilborn, J., Evans, N. D., Dreiss, C. A., … Gentleman, E. (2020). ILC1 drive intestinal epithelial and matrix remodelling. Nature Materials, 1–10. https://doi.org/10.1038/s41563-020-0783-8 Cite
Abstract
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