type-1 innate lymphoid cells

[Journal of Experimental Medicine] Genetic fate-mapping analysis revealed that liver Ly49E+ ILC1s with strong cytotoxicity originated from embryonic non–bone marrow hematopoietic progenitor cells, persisted locally during postnatal life, and mediated protective immunity against cytomegalovirus infection in newborn mice.

[Proceedings of the National Academy of Sciences of the United States of America] Using Zfp683 reporter mice, scientists showed that correlation of Hobit expression with type 1 innate lymphoid cells was tissue- and context-dependent.

[Clinical Cancer Research] Investigators combined radiation, immunotherapies, genetic mouse models, and antibody depletion experiments to identify the role of NK cells in overcoming resistance to radiation therapy in orthotopic models of head and neck squamous cell carcinoma

[Hepatology] Investigators found high expression of RORα in liver-resident NK cells/ILC1s. Mice with conditional ablation of Rora in LrNK cells/ILC1s and conventional NK (cNK) cells had decreased LrNK cells/ILC1s but normal numbers of cNK cells.

[Nature Materials] An immune cell population enriched in inflamed gut tissue is shown to play a role in driving CD44+ intestinal organoid proliferation, while also regulating ECM deposition and remodeling in a synthetic hydrogel platform.

[Immunity] Scientists demonstrated that type 1 innate lymphoid cells were the major immune force providing early protection during acute oral mucosal viral infection.