Publication

[Stem Cells] Researchers modulated WNT, Activin/Nodal, and MAPK signaling pathways by stage-specific addition of small molecule regulators CHIR99021, SB431542, and LY294002, respectively, and measured the impact on hematoendothelial formation in culture.

[Scientific Reports] The authors investigated the effects of pinostrobin (PN) on proliferation inhibition and induction of apoptosis, as well as the involvement of miRNAs in PN-mediated apoptosis in acute leukemia.

[Genes Chromosomes & Cancer] Investigators used RNA-seq to study the clinical significance of MYB expression and MYB alternative promoter (TSS2) usage in 133 pediatric acute lymphoblastic leukemia. RNA-seq revealed that all cases analyzed overexpressed MYB and demonstrated MYB TSS2 activity.

[Blood] Scientists performed germline and somatic targeted sequencing in a large cohort of adult patients with cytopenia and hypoplastic bone marrow to study germline predisposition variants and their clinical correlates.

[British Journal of Haematology] To evaluate the prognostic impact of complex karyotype and/or monosomal karyotype in combination with various clinical factors on allogeneic stem cell transplantation (HSCT) outcomes of patients with AML, researchers analyzed the registry database of adult AML patients who underwent allogeneic HSCT between 2000 and 2019 in Japan.

[Cell Reports] Researchers identified androgen receptor genomic and non-genomic actions that enhance glucagon-like peptide-1-stimulated insulin exocytosis in male β cells.