Publication

[Journal Of Infectious Diseases] Investigators improved their understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and the long-lasting durability of childhood smallpox vaccination-mediated immune responses including in people living with HIV.

[Arteriosclerosis Thrombosis And Vascular Biology] Researchers used systems biology approaches including proteomics, transcriptomics, and mass cytometry to define the circulating proteome and circulating immune cell phenotypes in subjects with COVID-19.

[Chemical Communications] Scientists reported newly designed tripeptides that were able to trigger proinflammatory cytokine (IL-12 and IFN-γ) secretion by CD4+CD44+ T cells in response to Leishmania donovani infection.

[International Immunopharmacology] Investigators explored whether interleukin-2/anti-interleukin-2 complex (IL-2C) alleviated lung inflammation in chronic obstructive pulmonary disease (COPD) by increasing the number of Tregs.

[Human Cell] Researchers identified 59 upregulated inflammation- and immune-related genes (IIRGs) in clear cell renal cell carcinoma from The Cancer Genome Atlas database. Among the upregulated IIRGs, nucleotide binding oligomerization domain 2 (NOD2), PYD and CARD domain (PYCARD) were also confirmed to be upregulated in the Oncomine database and in three independent GEO data sets.

[Nature Communications] Researchers identified that the squamous cell carcinomas-master transcription factor TP63 suppressed interferon-γ signaling. TP63 inhibition led to increased CD8+ T cell infiltration and heightened tumor killing in in vivo syngeneic mouse model and ex vivo co-culture system, respectively.