Publication

[Cancer Immunology Research] Investigators showed that patient-derived triple-negative breast CSCs were efficiently recognized and killed by ex vivo expanded γδ T cells from healthy donors. Orthotopically xenografted BCSCs, however, were refractory to γδ T-cell immunotherapy.

[Stem Cell Research & Therapy] Spheroid cells from endometrial cancer cell lines, Ishikawa and HEC1A, exhibited increased colony forming, subsphere forming, chemo-drug resistance, migration, invasion ability, and tumorigenicity, verifying their cancer stem-like cell properties.

[Cancer Science] Using drug reposition, researchers investigated a therapeutic drug for glioma-initiating cells. Drug screening was undertaken to select candidate agents that inhibit proliferation of two different glioma-initiating cells lines.

[Biochemical Pharmacology] The authors reported a liposome loaded with low toxicity and high effectiveness of miriplatin, lipo-miriplatin with high miriplatin loading, and robust stability, exhibiting a superior inhibitory effect on CSCs and non-CSCs.

[Aging] Scientists found that lncRNA-AC026356.1 was upregulated in stem spheres and chemo-resistant lung cancer cells. Fish assay also showed that AC026356.1 was predominantly located in the cytoplasm of lung cancer cells and did not have protein-coding potential.

[Cellular Signalling] Investigators inspected the functions of inorganic pyrophosphatase 1 (PPA1) in colorectal cancer (CRC). The abundance of PPA1 in CRC tissues was analyzed by utilizing publicly available data from the The Cancer Genome Atlas and Human Protein Atlas project.