Publication

[Cancer Research] Scientists described a strategy to develop phage-display libraries of nanobodies against ECM proteins expressed in human metastases, using as immunogens entire ECM-enriched preparations from triple-negative breast cancer and colorectal carcinoma metastases to different organs as immunogens.

[Applied Biochemistry And Biotechnology] The authors investigated the effect of nimbolide on A549 human NSCLC cells. They found that NB treatment inhibits A549 cells colony formation in a dose-dependent manner.

[Thoracic Cancer] The authors determined the nonclassical mechanism of Wee1 on DNA repair regulation. Western blot was conducted to determine the mono-ubiquitination level of H2Bub.

[Journal Of Cellular Physiology] Researchers demonstrated that SIRT6 was predominantly expressed in alveolar epithelial cells in human lung tissues by using a single-cell sequencing database.

[Science Translational Medicine] Investigators used single-cell cloning technologies to generate “libraries” of basal stem cells from the distal lungs of 16 patients with idiopathic pulmonary fibrosis and 10 controls.

[Biomaterials Research] To establish models that mimic the lung complexity to different extents, we used five design components: cell type, membrane structure/constitution, environmental conditions, cellular arrangement, substrate, matrix structure and composition.