Publication

[Nature Communications] To improve PDAC therapy, researchers established screening systems based on organoid and co-culture technologies and found a payload of antibody–drug conjugate, a bromodomain and extra-terminal (BET) protein degrader named EBET.

[Cell Reports Medicine] Investigators showed that PRMT1 was highly expressed in murine and human pancreatic cancer and was essential for cancer cell proliferation and tumorigenesis.

[Molecular Cell] Researchers revealed that H2AK119ub1 had two distinct roles in gene expression, through differentially modulating chromatin compaction mediated by canonical polycomb repressive complex 1 (PRC1) and the linker histone H1.

[Autophagy] Investigators demonstrated that macroautophagy/autophagy-related protein ATG5 inhibited the inflammatory response of mouse ESCs by promoting the degradation of BTRC/β-TrCP1 and further the downregulation of NFKB/NF-κB signaling.

[Environmental Pollution] Researchers focused on the characterization of the genetic traits and alterations in pluripotency/stemness triggered by phthalate ester derivatives. They reported the abilities of ESCs regarding proliferation, cell-cycle control, and neural ectoderm differentiation.

[Regenerative Therapy] Scientists increased the efficiency of generating cardiomyocytes from hPSCs. They identified cell death as a detrimental factor during this initial stage of in vitro cardiomyocyte differentiation.