Manumycin Polyketides Act as Molecular Glues between UBR7 and P53

Using chemoproteomic platforms, investigators showed that members of the manumycin family of polyketides, which bore multiple potentially reactive sites, targetted C374 of the putative E3 ligase UBR7 in breast cancer cells, and engaged in molecular glue interactions with the neosubstrate tumor-suppressor TP53, leading to p53 transcriptional activation and cell death.
[Nature Chemical Biology]
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Mechanical Strain Induces Phenotypic Changes in Breast Cancer Cells and Promotes Immunosuppression in the Tumor Microenvironment

Researchers demonstrated that exposure to mechanical strain promoted invasive and pro-tumorigenic phenotypes in breast cancer cells, indicating that mechanical strain could impact the growth and proliferation of cancer cell, alter exosome production by breast cancer, and induce immunosuppression in the tumor microenvironment by dampening anti-tumor immunity.
[Laboratory investigation]
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YES1 Amplification Confers Trastuzumab–Emtansine (T-DM1) Resistance in HER2-Positive Cancer

The authors revealed that YES1 amplification conferred resistance to HER2-targeted drugs.
[British Journal of Cancer]
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LNC942 Promoting METTL14-Mediated m6A Methylation in Breast Cancer Cell Proliferation and Progression

Investigators unveiled that LINC00942 exerted its functions as an oncogene in promoting METTL14-mediated m6A methylation and regulating the expression and stability of its target genes CXCR4 and CYP1B1 in breast cancer initiation and progression.
[Oncogene]
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Gremlin-1 Augments the Oestrogen-Related Receptor α Signalling through EGFR Activation: Implications for the Progression of Breast Cancer

Researchers found that GREM1 knockdown inhibited the proliferation of breast cancer cells and xenograft mammary tumour growth, while its overexpression enhanced their viability, growth and invasiveness. Oestrogen-related receptor α, an orphan nuclear hormone receptor, directly interacted with the GREM1 promoter and increased the expression of GREM1.
[British Journal of Cancer]
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Cancer Cell Invasion of Mammary Organoids with Basal‐In Phenotype

Investigators described mammary organoids with a basal‐in phenotype where the basement membrane was located on the interior surface of the organoid.
[Advanced Healthcare Materials]
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FGFR4 Regulates Tumor Subtype Differentiation in Luminal Breast Cancer and Metastatic Disease

Scientists identified a subset of luminal A primary breast tumors to give rise to HER2-enriched subtype metastases, but remained clinically HER2 negative. By testing the unique genetic and transcriptomic features of these cases, they developed the hypothesis that FGFR4 likely participated in this subtype switching.
[Journal of Clinical investigation]
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Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4

Researchers identified that Transient Receptor Potential Vanilloid 4 (TRPV4), a mechanosensitive ion channel mediated lung fibroblast differentiation and D. farinae-induced airway remodeling via a novel TRPV4-NADPH Oxidase 4 interaction.
[Scientific Reports]
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TGFβ Activity Released from Platelet-Rich Fibrin Adsorbs to Titanium Surface and Collagen Membranes

The authors showed that platelet-rich fibrin-derived TGF-β activity adsorbed to titanium implants and collagen membranes indicated by the changes in gene expression and immunoassay analysis.
[Scientific Reports]
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Bioactive‐Tissue‐Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing

A decellularized cardiac extracellular matrix‐based nanocomposite hydrogel was developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization.
[Advanced Materials]
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Robust Detection of Undifferentiated iPSC among Differentiated Cells

Scientists presented a novel method for detecting residual undifferentiated iPSCs amongst directed differentiated cells of all three germ lineages. Marker genes, expressed specifically and highly in undifferentiated iPSC, were selected from single cell RNA sequence data to perform robust and sensitive detection of residual undifferentiated cells in differentiated cell products.
[Scientific Reports]
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