Publication

[Nature Cell Biology] SEL1L or HRD1 deficiency in macrophages specifically amplified STING signaling and immunity against viral infection and tumor growth.

[Nature] The authors showed that the gut microbiome downregulated PD-L2 expression and its binding partner repulsive guidance molecule b to promote anti-tumor immunity, and identified bacterial species that mediated this effect.

[Cancer Research] To analyze responsiveness of gastric cancer to PARP inhibitor, scientists exploited a gastroesophageal adenocarcinoma platform of patient-derived xenografts (PDX) and PDX-derived primary cells and selected 10 PDXs with loss-of-function mutations in HR pathway genes.

[Journal of Experimental & Clinical Cancer Research] Investigators established a mouse model that replicated two common genetic and epigenetic events observed in human colorectal cancers: Apc mutation and p16 epimutation.

[Cell Reports] Researchers used in-depth quantitative proteomics combined with survival analysis, revealing that the ribosome protein U3 small nucleolar RNA-associated protein 18 homolog (UTP18) was consistently upregulated in the progression of colorectal adenoma to carcinoma.

[Oncogene] Transcriptome results suggested that NSUN2 expression was significantly upregulated in peritoneal metastasis (PM) and patients with high NSUN2 expression of PM predicted a worse prognosis.