Publication

[Journal Of Cell Biology] Researchers demonstrated that G2 cells were required to initiate normal levels of Ca2+ signaling, while connexin43 connected basal cells to orchestrate tissue-wide coordination of Ca2+ signaling.

[Cell Death Discovery] The expression of NCOA4, a key factor that influences ferritinophagy, was decreased in both diabetic wound tissue and high glucose-induced senescent fibroblasts.

[Scientific Reports] XTT and LDH tests on fibroblasts and keratinocytes were performed to assess the cytotoxicity of the RADA16-I hybrids, while the viability of cells treated with RADA16-I hybrids was evaluated in a model of human dermal fibroblasts.

[iScience] Researchers found that heat stress promoted melanogenesis in pigment cells by increasing the paracrine effects of keratinocytes, and high-throughput RNA sequencing showed that heat stress activated the Hedgehog (Hh) signaling pathway in keratinocytes.

[Cancer Immunology Research] Systemic administration of mWTX-330 in mice was well tolerated, resulted in robust antitumor immunity in multiple tumor models, and preferentially activated tumor-infiltrating immune cells rather than immune cells present in peripheral tissues.

[European Respiratory Journal] Using a mouse model of lung fibrosis, scientists demonstrated that the instillation of antibodies targeting the endogenous protein periplakin, mimicking naturally occurring autoantibodies seen in patients, directly to the lung increased lung injury, inflammation, collagen and fibronectin expression.