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Cbl-B Mitigates the Responsiveness of Naive CD8+ T Cells That Experience Extensive Tonic T Cell Receptor Signaling

[Science Signaling] The authors investigated how relatively weak or strong tonic T cell receptor signals influence naive CD8+ T cell responses to stimulation with foreign antigens.

Potent and Broadly Neutralizing Antibodies Against Sarbecoviruses Induced by Sequential COVID-19 Vaccination

[Cell Discovery] Scientists identified both potent and broadly neutralizing antibodies from a five-dose vaccinated donor who exhibited cross-reactive serum-neutralizing activity against diverse coronaviruses.

SARS-CoV-2 Vaccination May Mitigate Dysregulation of IL-1/IL-18 and Gastrointestinal Symptoms of the Post-COVID-19 Condition

[NPJ Vaccines] Investigators analyzed the plasma levels of 25 cytokines and SARS-CoV-2 directed antibodies in 540 individuals with or without post-COVID-19 conditions relative to one or two mRNA-based COVID-19 vaccinations as well as in 20 uninfected individuals one month after their initial mRNA-based COVID-19 vaccination.

Epigenetic and Transcriptional Regulation of Cytokine Production by Plasmodium falciparum-Exposed Monocytes

[Scientific Reports] Scientists provided molecular evidence that histone 3 lysine 4 methylation was key for inflammatory cytokine production in P. falciparum-exposed monocytes.

A Non-Human Primate Model for Human Norovirus Infection

[Nature Microbiology] Researchers established rhesus macaques as an animal model for human norovirus infection. They showed that rhesus macaques are susceptible to oral infection with human noroviruses from two different genogroups.

The Host RNA Polymerase II C-terminal Domain Is the Anchor for Replication of the Influenza Virus Genome

[Nature Communications] Investigators provided evidence that the FluPol-RNAP II binding interface, beyond its well-acknowledged function in cap-snatching during transcription initiation, had also a pivotal role in replication of the viral genome.

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