Publication

[Journal of Experimental Medicine] Investigators describe a parallel B cell–intrinsic mechanism contributing to breaks in tolerance. NOX2-deficient B cells exhibited enhanced signaling downstream of endosomal Toll-like receptors, increased humoral responses to nucleic acid-containing antigens, and the propensity toward humoral autoimmunity.

[Science Translational Medicine] Scientists found that anti-CD20 treatment effectively spared myelin content and prevented myeloid cell activation, oxidative damage, and mitochondrial stress in the subpial gray matter.

[Science Translational Medicine] Investigators reported modified immunocytokines consisting of Fc-optimized CD19 and CD20 antibodies fused to an IL-15 moiety comprising an L45E-E46K double mutation.

[Nature Medicine] Using single-cell analysis, scientists characterized the cellular identities present in human amniotic fluid. They identified and isolated viable epithelial stem/progenitor cells of fetal gastrointestinal, renal, and pulmonary origin.

[Stem Cell Research & Therapy] Investigators established intestinal organoids from enterocyte-like cells generated using our protocol. Furthermore, monolayers were produced from the organoids.

[Lab On A Chip] The authors presented a thermoplastic-based microphysiological system aiming to model the complex microphysiological structure and function of the endocrine pancreas with concurrent real-time read-out capabilities.