Publication

[Science Advances] ScRNA-seq identified a specific touch dome keratinocyte marker, Tenascin-C (TNC). Lineage tracing of Tnc-expressing touch dome keratinocytes revealed that these cells maintained themselves as an autonomous epidermal compartment and gave rise to Merkel cells upon injury.

[Burns & Trauma] The experiments used human bone marrow mesenchymal stem cells from the American Type Culture Collection, an in vivo mouse model of diabetes to assess wound healing, as well as the human keratinocyte HaCaT cell line.

[Lab On A Chip] Investigators developed a multi-lineage, fully-integrated, cardiovascular organ chip that could enhance human induced pluripotent stem cell (hiPSC)-endothelial cell and hiPSC-cardiomyocyte functional and genetic maturity, model endothelial barrier permeability, and demonstrate long-term functional stability.

[Current Eye Research] Scientists examined the effects of metformin on pathological angiogenesis and mTORC1 activity in the retinas of mice with oxygen-induced retinopathy. Metformin had no significant inhibitory effect on the expression of VEGF and VEGFR2, but it reduced the pS6 immunoreactivity in vascular cells at the sites of angiogenesis.

[Molecular And Cellular Biology] Investigators identified transcription factors regulating CD157 expression in endothelial cells (EC) that were associated with drug resistance, angiogenesis, and EC proliferation.

[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] Researchers investigated molecular differences between simple two-dimensional and more complex three-dimensional angiogenesis assays and compared them to in vivo data from cancer-associated angiogenesis using an unbiased transcriptomic analysis.