Publication

[Development] Scientists reported that zebrafish integrin beta 4 was a useful marker for basal cell labelling, irrespective of the body region, stage and regenerative status.

[Nature] The authors introduced an improved single-cell lineage tracing system based on deep detection of naturally-occurring mitochondrial DNA mutations with simultaneous readout of transcriptional states and chromatin accessibility.

[Nature Communications] Scientists showed that iron was increasingly taken up by HSCs during anemia and induced erythroid gene expression and regeneration in a Tet2-dependent manner.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators used inducible clonal DNA barcoding of endogenous adult HSCs to trace their contribution to major hematopoietic cell lineages in unmanipulated animals.

[Blood] Researchers explored the feasibility of immunotherapeutically targeting neoantigens, which arise from recurrent non-synonymous mutations in AML, and thus represent attractive targets since they are exclusively present on the tumor.

[International Journal Of Biological Macromolecules] Researchers found that lncRNA SNHG3, a highly expressed lncRNA in CRPC via bioinformatics analysis, promoted the invasive ability and the Enz resistance of the prostate cancer cells.