Publication

[Neoplasia] Scientists took a multifaceted approach from in vitro and in vivo experiments to validate the relationship between RUNX2 and TGF-β and to search for their pathogenic mechanisms in chemoresistance.

[Journal Of Clinical Investigation] Investigators characterized the repertoire of MHC I–associated peptides presented by hormone receptor–positive breast cancer and TNBC tumors. They identified 25 tumor-specific antigens mainly deriving from aberrantly expressed regions.

[Journal Of Cell Science] By analyzing previously published single-cell RNA sequencing datasets, scientists established the existence of a subpopulation of cells in primary tumors, secondary sites, and circulatory tumor cell clusters of highly aggressive TNBC that co-express mesenchymal stem cells and cancer-associated fibroblast markers.

[PLOS Pathogens] Scientists showed that T-bet-deficient mice develop robust Th17 responses and that mice deficient in Th17 cells exhibit delayed bacterial clearance, demonstrating that Chlamydia-specific Th17 cells represent an underappreciated protective population.

[Virus Research] An immunocompetent hepatitis B virus (HBV) CBA/CaJ mouse model and a co-culture model were used to explore the effect of sulforaphane (SFN) on HBV and whether SFN altered the immune balance after HBV infection.

[Journal Of Virology] Investigators extensively investigated the Zika virus (ZIKV)-specific T cell immunity in immune-privileged organs in Ifnar1−/− mice, based on an immunodominant epitope E294-302 tetramer.