Publication

[Cell Reports] The authors uncovered the spatiotemporal dynamics of early active hematopoiesis, using a highly sensitive in vivo imaging system. They developed expanded common myeloid progenitors, which exhibited a gene expression pattern that selectively proliferated in the spleen and promoted hematopoietic expansion.

[Communications Biology] Investigators showed that NLRP7 knockout affected the genetic stability, resulting in increased DNA damage in both human embryonic stem cells and blastoids, making embryonic cells in blastoids more susceptible to apoptosis.

[Cancer Gene Therapy] Scientists established a novel type of CAR-NK cells by integrating CAR sequences into the GAPDH 3’UTR locus of NK-92MI cells, achieving site-specific integration of the CAR gene and allowing endogenous regulatory components to govern CAR expression.

[Cell Death & Disease] Using genetically engineered mice, researchers showed that Trp53 deficiency in Pten-null prostatic epithelial cells did not impact early cell proliferation and neoplasia formation, nor growth arrest, and senescence entry at a later time.

[Cell Reports] Researchers found that the cleavage and polyadenylation specificity factor (CPSF) complex factor CPSF1 was upregulated in patients with advanced prostate cancer, with high CPSF1 expression correlating with worse progression-free survival.

[Journal of Biological Chemistry] Scientists utilized zebrafish and mouse models with inducible knockdowns of deoxyhypusine synthase and eukaryotic translation initiation factor 5A (eIF5A) to investigate their roles in cellular growth.