Publication

[Cell Biology International] Investigators found that Staphylococcus aureus treatment promoted the accumulation of iron, Fe2+, lipid peroxide, and malondialdehyde, increased TFRC and reduced FTH1 and GPX4 to trigger ferroptosis in rat bone marrow mesenchymal stem cells.

[Nature Communications] Investigators revealed that placenta-expressed transcript 1 (Plet1) was released from alveolar macrophages, and acted as important mediator of macrophage-epithelial cross-talk during lung repair by inducing proliferation of alveolar epithelial cells and re-sealing of the epithelial barrier.

[Scientific Reports] Investigators found a cytokine signature in patients receiving vedolizumab who were seropositive compared with seronegative for SARS-CoV-2 antibodies that may be linked to repeated SARS-CoV-2 infections.

[Advanced Functional Materials] fiber alignment gradients in biopsy samples are characterized and recreated using a new microfluidic biofabrication technique to achieve tunable sub-millimeter to millimeter scale gradients. Migration experiments on graded alignment show that humanumbilical vein endothelial cells (HUVECs) exhibit increased directionality, persistence, and speed compared to uniform and unaligned fiber architectures.

[Nature Communications] Researchers presented a human apical-out airway organoid using a biochemically defined hybrid hydrogel system. During human nasal epithelial progenitor cell differentiation, the gel gradually degraded, leading to the organoid apical surfaces facing outward. The expression and activity of ECM-degrading enzymes, matrix metalloproteinases increases during organoid differentiation, where inhibition of MMPs significantly suppresses the normal ciliation, resulting in increased goblet cell proportion.

[Nature Communications] Scientists introduced a fully-implantable wireless-powered tactile sensory system embedded in artificial skin, with stable operation, to restore permanently damaged tactile function and promote wound healing for regenerating severely damaged skin.