Publication

[Human Cell] Researchers found that the amniotic fluid derived MSCs (AFMSCs) could be categorized into three distinct groups: kidney-specific AFMSCs, lung-specific AFMSCs, and AFMSCs with an undefined tissue source.

[Transplantation And Cellular Therapy] The authors retrospectively analyzed the effects of conditioning regimens and graft-versus-host disease prophylaxis on the outcomes of umbilical cord blood transplantation performed with cyclophosphamide/total-body irradiation-based regimens in patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, and lymphoma.

[NPJ Precision Oncology] Investigators comprehensively unraveled the intra-patient response heterogeneity and intrinsic aggressive nature of PDAC on bulk and single-organoid resolution.

[Acta Pharmacologica Sinica] The authors showed that SMAD4 status almost determined the orientation of transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition via the SMAD4-dependent canonical pathway in PDAC, which altered ferroptosis vulnerability.

[Advanced Science] Researchers highlighted the important roles of basic helix-loop-helix transcription factor 40 (BHLHE40)-mediated lipid peroxidation in inducing ferroptosis in pancreatic cancer (PCa) cells and provided a novel mechanism underlying sterol regulatory element-binding factor 1 (SREBF1) overexpression in PCa.

[Aging] Scientists discovered that miR-211-5p was a significantly downregulated miRNA in pancreatic cancer tissues compared to adjacent non-tumour tissues.