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Immunology of Infectious Disease News
A Natural Product YSK-A Blocks SARS-CoV-2 Propagation by Targeting Multiple Host Genes
[Scientific Reports] Investigators used YSK-A, a mixture of three herbal components Boswellia serrata, Commiphora myrrha, and propolis, to evaluate potential antiviral activity against SARS-CoV-2.
Immunology of Infectious Disease News
Integrin α5β1 Contributes to Cell Fusion and Inflammation Mediated by SARS-CoV-2 Spike via RGD-Independent Interaction
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists revealed that SARS-CoV-2 spike protein exploited α5β1 signaling to facilitate cell–cell fusion and trigger inflammatory responses through the interaction with α5β1.
Mesenchymal Cell News
CXCL10 and Nrf2-Upregulated Mesenchymal Stem Cells Reinvigorate T Lymphocytes for Combating Glioblastoma
[Journal Of Immunotherapy] MSCs were transduced with a recombinant lentivirus encoding Cxcl10, Nrf2, and a ferritin heavy chain reporter gene to increase their CXCL10 secretion, tumor microenvironment survival, and MRI visibility.
Endothelial Cell News
Differential Roles of eNOS in Late Effects of VEGF-A on Hyperpermeability in Different Types of Endothelial Cells
[Scientific Reports] Scientists showed that VEGF-A induced hyperpermeability via endothelial nitric oxide synthase (eNOS)-dependent and eNOS-independent mechanisms at 2 days after VEGF-A stimulation.
Intestinal Cell News
An Injectable Subcutaneous Colon-Specific Immune Niche for the Treatment of Ulcerative Colitis
[Nature Biomedical Engineering] Scientists showed, in three mouse models of established ulcerative colitis, that a subcutaneously injected colon-specific immunosuppressive niche reduced inflammation in the animals’ lower gastrointestinal tract.
Intestinal Cell News
Role of PDGFRA+ Cells and a CD55+ PDGFRALo Fraction in the Gastric Mesenchymal Niche
[Nature Communications] Investigators shed light on spatial, molecular, and functional organization of gastric mesenchyme and the spectrum of signaling sources for epithelial support.