Publication

[Nature Communications] Investigators conducted a single-cell multi-omics analysis of transcriptional, clonal, and phenotypic profiles from pre- to one-month post-infusion of CAR+ and CAR− T cells from patients from a CARTELL study who received a donor-derived 4-1BB CAR product targeting CD19.

[Cell Death & Disease] Mechanically, bromodomain-containing protein 4 (BRD4) controlled the splicing efficiency of the RNA precursor of acyl-CoA synthase 3 (ACSL3) by recruiting serinerich/threonine protein kinase 2 (SRPK2) to assemble the splicing catalytic platform.

[Brain Research] Investigators found that administration of human umbilical cord MSC-exosome suppressed traumatic brain injury-induced inflammation and ferroptosis.

[Journal of Applied Genetics] Scientists analyzed the functions of atypical chemokine receptor 1 (ACKR1) in sarcoma progression and its potential mechanism.

[Dental Materials Journal] The authors investigated whether induced pluripotent stem cells could be differentiated into MSCs using MSCGM, a commercially available MSC culture system.

[Free Radical Biology and Medicine] By obtaining humanized fust-1 amyotrophic lateral sclerosis (ALS) mutations via CRISPR-CAS9, investigators generated a C. elegans ALS model. Homozygous fust-1 ALS mutant and fust-1 deletion animals are viable in C. elegans.