Publication

[Nucleic Acids Research] The authors examined YAP1/TAZ-TEAD signaling pathway activity at neuromuscular junctions of skeletal muscle fibers in adult mice.

[Nature] Scientists used cryogenic electron microscopy to determine the structures of amyloid filaments extracted from the prefrontal and temporal cortices of four individuals with frontotemporal lobar degeneration–FUS.

[Cellular & Molecular Immunology] Using single-cell RNA sequencing, researchers found that APG-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion, restoring T-cell function and promoting a favorable immunotherapy response.

[Nature Communications] Following intratracheal aerosol delivery of Cy5-labeled peptide in rhesus macaques, the authors confirmed delivery throughout the respiratory tract.

[Scientific Reports] The in vitro cytotoxicity of the 17 semisynthesized derivatives of renieramycin S against human NSCLC cells in parallel with normal cell lines was evaluated.

[Small] An injectable hydrogel microsphere system focusing on the hypoxic inflamed joint was prepared with methacrylate-modified sulfonated azocalix[4]arene, methacrylated hyaluronic acid, and dithiol-terminated matrix metalloproteinase 13 sensitive peptide via a microfluidic device and photo crosslinking technique.