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Beta-Cell Intrinsic Dynamics Rather Than Gap Junction Structure Dictates Subpopulations in the Islet Functional Network
[eLife] Researchers used experimental and computational techniques to investigate the relationship between functional networks, structural networks, and intrinsic -cell dynamics in slow and fast oscillating islets.
Newsletters
Disrupted Hypothalamic Transcriptomics and Proteomics in a Mouse Model of Type 2 Diabetes Exposed to Recurrent Hypoglycaemia
[Diabetologia] Scientists identified the changes in hypothalamic gene and protein expression that underlie impaired counterregulatory response (CRR) in a mouse model of defective CRR.
ESC & iPSC News
Hypoblast From Human Pluripotent Stem Cells Regulates Epiblast Development
[Nature] The authors reported genetic and non-genetic approaches to generate authentic hypoblast cellsfrom naïve human PSCs.
ESC & iPSC News
The Circadian Regulator PER1 Promotes Cell Reprogramming by Inhibiting Inflammatory Signaling From Macrophages
[PLOS Biology] Investigators found that one of the master circadian regulators PER1 promoted virus-mediated reprogramming of mouse embryonic fibroblasts to induced neurons and iPSCs.
Mesenchymal Cell News
Boosting the Therapeutic Potential of Cell Secretome Against Osteoarthritis: Comparison of Cytokine-Based Priming Strategies
[Biomedicine & Pharmacotherapy] Scientists compared the composition of the conditioned medium obtained after 24 or 72 h from untreated and cytokine-treated adipose-derived MSCs.
Mesenchymal Cell News
Local Manufacturing Processes Contribute to Variability in Human Mesenchymal Stromal Cell Expansion While Growth Media Supplements Contribute to Variability in Gene Expression and Cell...
[Cytotherapy] Scientists assessed the impact on MSC expansion, gene expression, and other characteristics when different laboratories expanded MSCs from cultures initiated with bone marrow−MSC aliquots derived from the same donor source material yet with different growth media.