Publication

[Brain] Scientists identified two vital missense variants of G protein-coupled receptor-associated sorting protein 1 (GPRASP1) in arteriovenous malformations patients for the first time and congruously determined to be loss-of-function variants in endothelial cells.

[Nature Communications] Researchers demonstrated that the expression of fibroblast growth factor 18 (Fgf18) was elevated in mouse livers following the induction of chronic liver fibrosis models.

[Cell Death & Disease] Investigators explored the potential function and the underlying mechanisms of endothelial cell-derived R-spondin 3 (RSPO3) neuroprotection against ischemia/reperfusion-induced neuronal cell injury.

[Acta Pharmacologica Sinica] Scientists identified a potential novel covalent extracellular regulated protein kinase (ERK) inhibitor, Laxiflorin B, which is a herbal compound with anticancer activity.

[Cell Death & Disease] Taking advantage of human lung adenocarcinoma cells, researchers revealed that MCT4 can be polyubiquitylated in a nonproteolytic manner by SYVN1 E3 ubiquitin ligase.

[Communications Biology] Scientists determined that miR-3913-5p was downregulated in colorectal cancer (CRC) cell lines and CRC tissues. Exogenous miR-3913-5p expression weakened the CRC cell's growth, migration, and invasion.