Publication

[Current Stem Cell Research & Therapy] Researchers investigated for the first time the role of gut microbiota in mediating the protective effect of human umbilical cord MSCs on 2% dextran sodium sulfate-induced colitis. Gut microbiota alteration and short-chain fatty acids production were analyzed through 16S rRNA sequencing and targeted metabolomics.

[Acta Biomaterialia] Vasculogenic hydrogels were embedded within a highly porous, biostable 3D polydimethylsiloxane scaffold.

[Journal Of Crohns & Colitis] Inhibition of NLRP3 caused significantly reduced proliferation of intestinal fibroblasts from inflammatory bowel diseases patients, which was associated with a marked decrease in production of collagen type I and type VI.

[Cell Reports] Scientists demonstrated that the softer matrix microenvironment induces a shift in glioblastoma cell metabolism toward glycolysis, which manifested in lower proliferation rate and increased migration activities.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] By high-resolution imaging, researchers observed a direct transfer of fluorescently tagged ROR2 from cancer-associated fibroblasts to the gastric cancer cell line AGS cells by signaling filopodia, known as cytonemes.

[Nature Cell Biology] Investigators reported curvature-dependent integrin-mediated adhesions called curved adhesions. Their formation was regulated by the membrane curvatures imposed by the topography of ECM protein fibres.