Publication

[Cell Death & Disease] The authors identified the Ring Finger Protein 40 monoubiquitinating histone 2B at lysine 120 as an indispensable E3 ligase for sustaining the stem-cell-like features of the growing mammary gland.

[Endocrine-Related Cancer] Researchers reported that vemurafenib induced the expression of several stemness-related genes including Gli1, Snail, BMI1, and SOX2 in two anaplastic thyroid cancer cell lines, SW1736 and 8505C, but decreased the expression of these genes in A375 cells, a human melanoma cell line.

[Human Cell] Investigators established an laryngeal squamous cell carcinoma (LSCC) cell line from primary LSCC tumor tissue and adapted a culturing condition for the expansion of potential stem cells to isolate CSCs from FD-LS-6.

[Heliyon] Investigators employed decellularized human amniotic membrane (dHAM) as a bioactive ECM and modified it through methacrylate grafting for engineering purposes, resulting in the photosensitive dECMMA.

[Stem Cell Research & Therapy] Scientists elucidated the therapeutic effect and mechanism of the human umbilical cord MSCs in a mouse model of experimental allergic conjunctivitis.

[Nature Cell Biology] Using intracranial injections in mice and assembloids between small-cell lung cancer (SCLC) aggregates and human cortical organoids in culture, the authors found that SCLC cells recruited reactive astrocytes to the tumor microenvironment.