Publication

[Experimental & Molecular Medicine] Investigators demonstrated that the mRNA and protein levels of the class III histone deacetylase SIRT1 were upregulated by the kirsten rat sarcoma viral oncogene homologue (KRAS)Mut-Raf-MEK-c-Myc axis in KRASMut lung cancer cells and in lung tumors of a mouse model with spontaneous KrasG12D expression.

[Cell Death & Disease] Researchers reported that crotonylated brain expressed X-linked gene 2 (BEX2) plays an important role in inhibiting chemotherapeutic agent-induced apoptosis via enhancing mitophagy in human lung cancer cells.

[Scientific Reports] Scientists identified CSE1L as a novel inhibitor of the RBL2-DREAM pathway and target to activate RBL2-DREAM in NSCLC cells. CSE1L is an oncoprotein that maintains repression of genes that can be reactivated by HDAC inhibitors.

[Cell Reports Medicine] Scientists describe a second-generation FGFR4-targeting chimeric antigen receptor, based on an anti-human FGFR4-specific murine monoclonal antibody 3A11, as an adoptive T cell treatment for rhabdomyosarcoma.

[Heliyon] Researchers investigated the effect of NKG2D-based CAR T cell therapy on colorectal cancer cell lines, and then they assessed combinatorial therapy using NKG2D CAR T cells and lenalidomide in vitro.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] BRD4 directly stimulated transcripts expression of seven methyltransferase complex subunits, allowing the maintenance of the nuclear writer complex integrity.