Publication

[Annals Of Surgical Oncology] Researchers examined the expression profiles of ion transport-related molecules in the CSCs of esophageal adenocarcinoma.

[Functional & Integrative Genomics] Scientists explored the influence of myelin protein zero-like protein 1 (MPZL1) on the stem-like properties of cancer cells and the underlying mechanism in lung adenocarcinoma.

[Nature Medicine] In this Phase IIa, placebo-controlled, double-blinded trial, 43 people with HIV-1 on antiretroviral therapy were randomized to placebo/placebo, lefitolimod/placebo, placebo/broadly neutralizing anti-HIV-1 antibodies (bNAbs) or lefitolimod/bNAb.

[European Journal Of Immunology] Investigators explored the role of vaccine antigen-specific regulatory T (Treg) cells in antibody response to repeated annual influenza vaccination. They analyzed pre- and post-vaccination hemagglutination inhibition titers, seroconversion rates, seroprotection rates, vaccine antigen hemagglutinin-specific Treg cells, and conventional T cells.

[Journal Of Immunology] Scientists demonstrated that mycobacterial cell-wall glycolipids such as ManLAM could traffic from infected macrophages to disrupt productive immunological synapse formation and inhibit CD4+ T cell activation, contributing to immune evasion by M. tuberculosis.

[Developmental And Comparative Immunology] Researchers used a detoxified Salmonella Gallinarum (SG) strain to deliver a dual prokaryotic and eukaryotic expression vector, pJHL270 that expressed recombinant H9N2 antigens in both Salmonella and host cells. They evaluated the H9N2 antigen and SG-specific humoral and cellular immune responses in vitro following immunization.