Publication

[Nature Biomedical Engineering] Researchers reported a cancer vaccine consisting of polymer-coated NaErF4/NaYF4 core–shell down-conversion nanoparticles emitting luminescence in the near-infrared spectral window IIb and with surface-conjugated antigen and electrostatically complexed adjuvant.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers found that CD45, a membrane-bound tyrosine phosphatase essential for T cell development, negatively regulated group 2 innate lymphoid cells (ILC2s) in a cell-intrinsic manner.

[Cellular & Molecular Immunology] Investigators found that SEL1L deficiency led to a greatly reduced frequency and number of mature T cells, which was further validated by adoptive transfer experiments or bone marrow chimera experiments, accompanied by the induction of multiple forms of cell death.

[Nature] To systematically define the basis for the metabolic reprogramming supporting TRM cell differentiation, survival and function, investigators leveraged in vivo functional genomics, untargeted metabolomics and transcriptomics of virus-specific memory CD8+ T cell populations.

[Science Translational Medicine] An antibody against mouse triggering receptor expressed on myeloid cells-1 (TREM1), PY159m, promoted antitumor efficacy in syngeneic mouse tumor models.

[Cell Reports] Scientists demonstrated that CD4t umor-specific T (TTS) cells were quickly primed and began to divide following tumor initiation. However, unlike CD8 TTS cells or exhaustion programming, CD4 TTS cell proliferation was rapidly frozen in place by a functional interplay of regulatory T cells and CTLA4.