Publication

[Cell Reports] Using an antibody against CD25 that biases IL-2 signaling toward an alternative pathway, researchers established that this pathway increased the suppressive activity of Tregs and ameliorated murine experimental autoimmune encephalomyelitis.

[Immunity] Specific deletion of the nuclear isoform of retinoic acid receptor alpha (RARα) revealed an RARα isoform in the cytoplasm of T cells. Extranuclear RARα was rapidly phosphorylated upon T cell receptor stimulation and recruited to the T cell receptor signalosome.

[Science Immunology] The authors established an in vitro model of chronic stimulation and benchmarked key phenotypic, functional, transcriptional, and epigenetic features against bona fide in vivo exhausted CD8 T cells.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators found that tumor necrosis factor–like cytokine 1A/death receptor 3 promoted helper T (Th) 1 and Th7 cell differentiation in T-T and dendritic cell-T cell interaction-dependent manners.

[Nature] The most notable change observed in mice overexpressing naked mole-rat hyaluronic acid synthase 2 gene was attenuated inflammation across multiple tissues. High-molecular-mass hyaluronic acid reduced inflammation through several pathways, including a direct immunoregulatory effect on immune cells, protection from oxidative stress, and improved gut barrier function during aging.

[Science Advances] Whole tumor single-cell RNA sequencing analysis and blockade experiments revealed that the amphiregulin–epidermal growth factor receptor axis mediated cross-talk between IL1RL1+ Treg cells and cancer-associated fibroblasts.