Publication

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers generated malignant brain tumor domain containing 1 (Mbtd1) conditional knockout mice and analyzed adult hematopoietic tissues deficient in Mbtd1.

[EMBO Reports] Researchers performed an amino acid drop-out screen and applied pre-clinical models of chronic phase chronic myeloid leukemia (CML) to identify arginine as a nutrient essential for primary human CML cells.

[Frontiers in Oncology] Investigators examined the clinical significance of genes involved in iron-related cell death and apoptotic pathways in AML, with the intention of providing insights that could have prognostic implications and facilitate the development of targeted therapeutic interventions.

[FEBS Journal] Scientists examined whether DTX2 was involved in the regulation of RUNX1 using in vitro and ex vivo analyses. DTX2 bound to RUNX1 and other RUNX family members RUNX2 and RUNX3 through their C-terminal region.

[Leukemia] Researchers characterized the transcriptional and epigenetic landscape with the isocitrate dehydrogenase (IDH) 2i AG-221, using an IDH2 mutated AML cell line model and AML patient cohorts.

[European Journal of Haematology] A total of 59 consecutive subjects diagnosed with myelodysplasia, 48 with AML, and 17 with clonal cytopenia with unknown significance were screened for somatic mutations in AML-related genes by next-generation sequencing.