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Review
Human Immunology News
T Cell Receptor Therapeutics: Immunological Targeting of the Intracellular Cancer Proteome
[Nature Reviews Drug Discovery] The authors discuss the unique complexities associated with the clinical development of these therapeutics, such as HLA restriction, T cell receptor retrieval, potency assessment, and the potential for cross-reactivity.
Hepatic Cell News
Hepatocellular Carcinoma: Up-Regulated Circular RNAs Which Mediate Efficacy in Preclinical In Vivo Models
[Cancer Genomics & Proteomics] Scientists provide an overview of up-regulated circular RNAs which mediate efficacy in preclinical in vivo models of HCC.
Hepatic Cell News
Inflammatory Signaling in NASH Driven by Hepatocyte Mitochondrial Dysfunctions
[Journal of Translational Medicine] The authors consider the role of impaired mitochondrial function caused by lipotoxicity during oxidative stress in hepatocytes.
Intestinal Cell News
Systematic Review: Predictive Value of Organoids in Colorectal Cancer
[Scientific Reports] The authors present a systematic review of studies that have tested the performance of patient-derived organoids to predict the effect of anti-cancer therapies in colorectal cancer, for chemotherapies, targeted drugs, and radiation therapy.
Cancer Stem Cell News
Therapeutic Biomarkers in Metastatic Castration-Resistant Prostate Cancer: Does the State Matter?
[Critical Reviews In Clinical Laboratory Sciences] Investigators outline precision medicine in metastatic cCRPC, zooming in on the role of circulating tumor DNA, to identify genomic biomarkers that may be used to tailor molecularly targeted therapies.
Human Immunology News
Regulatory T Cells in Allergic Inflammation
[Seminars in Immunology] Interruption of Treg cell subversion in chronic allergic inflammatory conditions may provide novel therapeutic strategies by re-establishing effective immune regulation.