Review

[Cancer Cell International] The authors review the application of ideal histone deacetylases 2 (HDAC2) inhibitors with solid anti-tumor efficacy in combination with immunotherapy for HCC.

[Biomedicine & Pharmacotherapy] The authors explore the new therapeutic target of preeclampsia through oxidative stress in ferroptosis.

[Journal Of Clinical Investigation] The authors propose that vascular and endothelial cell abnormalities are both causal and consequential in the pathobiology of idiopathic pulmonary fibrosis and that fuller evaluation of dysregulated pathways may lead to effective therapies and a cure for this devastating disease.

[Cell Communication and Signaling] The authors summarize the current knowledge on the contribution of the inflammasomes in glioma and therapeutic insights.

[CNS Neuroscience & Therapeutics] Scientists elaborate mammalian target of rapamycin (mTOR) signaling network mainly in the brain, point to gaps of knowledge, and define how and in which ways mTOR signaling can be connected with Alzheimer's disease pathogenesis and symptoms.

[Neurotherapeutics] Investigators include the additional preclinical studies examining the efficacy of minocycline in preclinical traumatic brain injury (TBI) models as well as recommendations for a clinical trial to test minocycline to treat TBI.