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Enhancing HCC Treatment: Innovatively Combining HDAC2 Inhibitor with PD-1/PD-L1 Inhibition

[Cancer Cell International] The authors review the application of ideal histone deacetylases 2 (HDAC2) inhibitors with solid anti-tumor efficacy in combination with immunotherapy for HCC.

Impact of Ferroptosis on Preeclampsia: A Review

[Biomedicine & Pharmacotherapy] The authors explore the new therapeutic target of preeclampsia through oxidative stress in ferroptosis.

Beyond Epithelial Damage: Vascular and Endothelial Contributions to Idiopathic Pulmonary Fibrosis

[Journal Of Clinical Investigation] The authors propose that vascular and endothelial cell abnormalities are both causal and consequential in the pathobiology of idiopathic pulmonary fibrosis and that fuller evaluation of dysregulated pathways may lead to effective therapies and a cure for this devastating disease.

Dysregulation of Inflammasome Activation in Glioma

[Cell Communication and Signaling] The authors summarize the current knowledge on the contribution of the inflammasomes in glioma and therapeutic insights.

mTOR Signaling and Alzheimer’s Disease: What We Know and Where We Are?

[CNS Neuroscience & Therapeutics] Scientists elaborate mammalian target of rapamycin (mTOR) signaling network mainly in the brain, point to gaps of knowledge, and define how and in which ways mTOR signaling can be connected with Alzheimer's disease pathogenesis and symptoms.

Treating Traumatic Brain Injury with Minocycline

[Neurotherapeutics] Investigators include the additional preclinical studies examining the efficacy of minocycline in preclinical traumatic brain injury (TBI) models as well as recommendations for a clinical trial to test minocycline to treat TBI.

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