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The Evolving Views of Hematopoiesis: From Embryo to Adulthood and from In Vivo to In Vitro

[Journal Of Genetics And Genomics] Scientists review the evolving views of HSPC biology during developmental and postnatal hematopoiesis. Moreover, we discuss recent advances in the in vitro induction and expansion of HSPCs, with a focus on the implications for clinical applications.

Epithelial Specific Splicing Regulator Proteins as Emerging Oncogenes in Aggressive Prostate Cancer

[Oncogene] Scientists discuss how expression of the splicing regulators ESRP1 and ESRP2, and how their role as “masterminds” of epithelial splicing patterns, have been identified as markers of aggressively proliferating prostate primary tumors.

Membrane Organization by Tetraspanins and Galectins Shapes Lymphocyte Function

[Nature Reviews Immunology] Scientists advocate for a novel approach to study lymphocyte function by globally analysing the role of membrane organizers in the assembly of different membrane complexes, and discuss opportunities to develop therapeutic approaches that act via the modulation of membrane organization.

Versatile Roles of Innate Lymphoid Cells at the Mucosal Barrier: From Homeostasis to Pathological Inflammation

[Experimental & Molecular Medicine] The authors discuss recent advances regarding our understanding of the biology of innate lymphoid cells in mucosal tissue health and disease.

Enhancement of the Therapeutic Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Osteoarthritis

[Cellular & Molecular Biology Letters] The authors provide a comprehensive overview of the biosynthesis and composition of MSC-Exos and their mechanisms of action in osteoarthritis.

Molecular Pathology of Neurodegenerative Diseases by Cryo-EM of Amyloids

[Nature] The authors review the structures of brain-derived amyloid filaments that have been determined so far and discuss their impact on research into neurodegeneration.

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