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Tools to Study Neural and Glioma Stem Cell Quiescence

[Trends In Neurosciences] The authors discuss the in vitro and in vivo models that have been developed for studying neural stem cell quiescence and how these tools may be used to deepen biological understanding and to develop novel therapies targeting quiescent glioma stem cells.

Differentiation and Regulation of CD4+ T Cell Subsets in Parkinson’s Disease

[Cellular and Molecular Life Sciences] The authors systematically review the differentiation of CD4+ T cell subsets, and focus on describing the functions and mechanisms of different CD4+ T cell subsets and their secreted cytokines in Parkinson’s disease.

Reshaping the Tumor Immune Microenvironment to Improve CAR-T Cell-Based Cancer Immunotherapy

[Molecular Cancer] The immunosuppressive microenvironment of tumors affects CAR-T cells, limiting the treatment’s effectiveness and safety. Therefore, enhancing CAR-T cell infiltration capacity and resolving the immunosuppressive responses within the tumor microenvironment could boost the anti-tumor effect.

A-to-I RNA Editing and Hematopoiesis

[Experimental Hematology] The authors focus on the role of adenosine-to-inosine (A-to-I) RNA editing and adenosine deaminase acting on RNA (ADAR) enzymes, particularly ADAR1, during normal hematopoiesis in humans and mice.

Advancements in Melanoma Immunotherapy: The Emergence of Extracellular Vesicle Vaccines

[Cell Death Discovery] The authors focus on the construction strategies for extracellular vesicles vaccines from various sources, their effects, and immunological mechanisms in treating melanoma, as well as the shortcomings and future perspectives in this field.

Recent Progress in Modeling and Treating Diabetes Using Stem Cell-Derived Islets

[Stem Cells Translational Medicine] The authors summarize recent advances using stem cell derived-islets to understand different diabetes pathologies and as a cell therapy.

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