Review

[Journal Of Endocrinology] Investigators describe how various nutrients are sensed, transported and metabolised in alpha cells, providing an integrative model for the metabolic regulation of glucagon secretion and action.

[Trends in Molecular Medicine] The authors discuss the reactive oxygen/nitrogen species (ROS/RNS)-related mechanisms underlying liver fibrosis of distinct etiologies and highlight preclinical and clinical trials of antifibrotic therapies premised on remediating oxidative/nitrosative stress in hepatocytes or targeting hepatic stellate cell activation.

[Nature Reviews Cancer] The authors specifically summarize the approaches so far applied to inhibit estrogen and androgen availability for receptor binding via inhibiting steroid biosynthesis.

[Trends In Biochemical Sciences] Scientists focus on novel STIM (stromal interaction molecule)-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function.

[Cell] The authors review how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system.

[International Journal Of Biological Macromolecules] The authors summarize the research on the treatment of inflammatory bowel disease by many natural plant polysaccharides, and provides a theoretical basis for the later treatment of polysaccharides on inflammatory bowel disease.