Publication

[International Journal Of Biological Sciences] An aging microenvironment index was constructed, with excellent prognostic and immunotherapy prediction ability, and its' clinical relevance was surveyed through spatial transcriptomics.

[Journal Of Experimental & Clinical Cancer Research] The impact of TOMM20 depletion on drug sensitivity were elucidated by assays of cell proliferation, invasion, sphere formation, xenograft growth, and intravenous metastasis.

[Chemosphere] Investigators demonstrated that antimony exposure promoted prostate cancer progression in vivo and in vitro.

[Journal Of Medicinal Chemistry] A representative compound, BWA-522, effectively induced degradation of both androgen receptor-FL and androgen receptor-V7, and was more potent than the corresponding antagonist against prostate cancer cells in vitro.

[Journal Of Medicinal Chemistry] Researchers validated the utility and selectivity of the compounds developped in cell-based models of prostate cancer.

[Cell Reports] A survey of receptor tyrosine kinases (RTKs) identified ROR2 as the top upregulated RTK following androgen receptor pathway inhibition, which fed into lineage plasticity by promoting stem-cell-like and neuronal networks.