Publication

[Nature Communications] Researchers showed that the mRNA vaccine BNT162b2 induced robust protective immunity in K18- human angiotensin-converting enzyme 2 transgenic B cell deficient mice.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists reported an inducible, transgenic human angiotensin–converting enzyme II (hACE2) mouse line and showcased three examples for specifically expressing hACE2 in three different lung epithelial cells.

[Science Signaling] Leveraging the golden hamster model of COVID-19, researchers elucidated the dynamics between SARS-CoV-2 infection in the airways and the systemic host response that ensues.

[mBio] Investigators found that the human coronaviruses HCoV-OC43, human coronavirus OC43, and SARS-CoV-2 both robustly activated the IRE1α–XBP1 branch of the unfolded protein response in cultured cells.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors discovered an important mechanism for blood–brain barrier disruption that was driven by unique features of histidine-rich protein II, a protein secreted by Plasmodium falciparum during the blood stage of malaria infection.

[Cell Reports] Using a CRISPR screen, investigators identified that murine cytomegalovirus (MCMV)-encoded chemokine 2 (MCK2)-dependent infection required MHC class Ia/β-2-microglobulin expression.