Publication

[Blood Cancer Journal] Investigators analyzed the outcome of rabbit anti-thymocyte globulin vs. post-transplantation cyclophosphamide prophylaxis in adult patients with hematologic malignancies undergoing first peripheral blood allogeneic stem cell transplantations from mismatched unrelated donors between Jan 2018 and June 2021 in the database of the European Society for Blood and Marrow Transplantation.

[Nature Communications] The authors describe a human liver chimeric transgene-free Il2rg−/−/Rag2−/−/Fah−/−/Aavr−/− (TIRFA) mouse model overcoming this translational roadblock, by combining liver humanization with AAV receptor (AAVR) ablation, rendering murine cells impermissive to AAV transduction.

[Advanced Science] Researchers presented a scaffold that facilitated the localized administration of the transforming growth factor β gene in the proximal region to accelerate nerve regeneration, while simultaneously delivering nicotinamide mononucleotide adenylyltransferase 2 to the distal region to mitigate Wallerian degeneration.

[European Journal Of Nuclear Medicine And Molecular Imaging] The authors evaluated the value of [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) combining with clinical indices and laboratory indicators in predicting outcomes and toxicity of anti-CD19 CAR T-cell therapy for diffuse large B-cell lymphoma patients.

[Biofabrication] 5% liver fibrosis serum was used to induce the therapeutic phenotype of MSCs, and a fluid bioreactor carrying a co-culture system of hepatocytes and MSCs was constructed to produce the therapeutic medium.

[Stem Cell Reviews And Reports] The authors investigated if osteopontin modulated cell senescence and bone regenerative function in human adipose-derived mesenchymal stem cells, and to determine the underlying mechanisms.