Publication

[Developmental Cell] By optogenetically targeting different nodes in the Ras/PI3K/Akt network in differentiated human HL-60 neutrophils, scientists abruptly altered protrusive activity, bypassing the chemoattractant receptor/G-protein network.

[Cell Reports] Investigators described the unexpected role of titin, the largest protein encoded by the human genome, in the regulation of mechanisms of lymphocyte trafficking.

[Nature Cancer] To interrogate potential roles of T cells in this process, the authors profiled these cells from individuals with primary or metastatic brain cancers via integrated analyses on the single-cell and bulk population levels.

[Journal of Immunology] Scientists reported that cancer cells could upregulate surface macrophage receptor with collagenous structure (MARCO) expression on human macrophages not only via IL-6–induced STAT3 activation but also via sphingosine-1-phosphate receptor-mediated IL-6 and IL-10 expression followed by STAT3 activation.

[Science Advances] Researchers demonstrated that histologically Sema4A-positive non–small cell lung cancer (NSCLC) responded significantly better to anti–programmed cell death 1 (PD-1) antibody than Sema4A-negative NSCLC.

[Immunology] The authors evaluated the impact of treatment with kifunensine, an inhibitor of asparagine-linked (N-)glycan processing, on antibody-dependent cell-mediated cytotoxicity using primary and cultured human NK cells.