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Acetylated KHSRP Impairs DNA-Damage-Response-Related mRNA Decay and Facilitates Prostate Cancer Tumorigenesis

[Molecular Oncology] The authors found that androgen could significantly induce acetylation of far upstream element-binding protein 2 (KHSRP), which intrinsically drove tumor growth in xenografted mice.

Stimulatory Effect of Methylglyoxal on Capsaicin-Sensitive Lung Vagal Afferents in Rats: Role of TRPA1

[American Journal Of Physiology-Regulatory Integrative And Comparative Physiology] Scientists showed that intravenous injection of methylglyoxal in anesthetized, spontaneously breathing rats elicited pulmonary chemoreflexes characterized by apnea, bradycardia, and hypotension.

Bile Acid Metabolites Enhance Expression of Cathelicidin Antimicrobial Peptide in Airway Epithelium through Activation of the TGR5-ERK1/2 Pathway

[Scientific Reports] Researchers investigated the effects of bile acid metabolites produced from lithocholic acid by microbiota, on the regulation of innate immune responses connected to the expression of host defense peptide cathelicidin in lung epithelial cells.

Small-Molecule Caspase-1 Inhibitor CZL80 Terminates Refractory Status Epilepticus via Inhibition of Glutamatergic Transmission

[Acta Neuropathologica] The authors highlighted the therapeutic potential of CZL80, a small molecule that inhibits caspase-1, in status epilepticus termination and its related mechanisms.

Reactivating PTEN to Impair Glioma Stem Cells by Inhibiting Cytosolic Iron-Sulfur Assembly

[Science Translational Medicine] The authors found that PTEN directly interacted with MMS19 and competitively disrupted MMS19-based cytosolic iron-sulfur cluster assembly machinery in differentiated glioma cells.

Loss of RNA-Binding Protein CELF2 Promotes Acute Leukemia Development via FAT10-mTORC1

[Oncogene] The authors showed that Celf2 deficiency in hematopoietic system led to enhanced HSCs self-renewal and differentiation toward myeloid cells in mice.

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