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LSD1 Controls a Nuclear Checkpoint in Wnt/β-Catenin Signaling to Regulate Muscle Stem Cell Self-Renewal

[Nucleic Acids Research] Scientists showed that β-Catenin was a substrate of lysine specific demethylase 1 (LSD1). Demethylation by LSD1 prevented β-Catenin degradation thereby maintaining its nuclear levels.

An Anti-Oxidative and Active Shrinkage Hydrogel Integratedly Promotes Re-Epithelization and Skin Constriction for Enhancing Wound Closure

[Advanced Materials] The antioxidative active-shrinkage hydrogel relieved overactivated inflammation, prevented cellular apoptosis, and promoted fibroblast migration in vitro by reducing excessive reactive oxygen species.

Macromolecular Crowding in Human Tenocyte and Skin Fibroblast Cultures: A Comparative Analysis

[Materials Today Bio] The authors compared human tenocyte and dermal fibroblast behavior under standard and macromolecular crowding conditions to inform future studies in tendon engineering.

Green Cocoon-Derived Sericin Reduces Cellular Damage Caused by Radiation in Human Keratinocytes

[Scientific Reports] Researchers investigated the effects of green cocoon-derived sericin on human keratinocytes using lactate dehydrogenase activity to indicate damage reduction.

Collagen I Protects Human Keratinocytes HaCaT against UVB Injury via Restoring PINK1/Parkin-Mediated Mitophagy

[Archives Of Biochemistry And Biophysics] Cells grown on plates coated by molecular collagen I, but not fibrillar collagen I, acquired certain resistance against UVB damages, as shown by increased survival and reduced apoptosis.

ANKRD1 Is a Mesenchymal-Specific Driver of Cancer-Associated Fibroblast Activation Bridging Androgen Receptor Loss to AP-1 Activation

[Nature Communications] Investigators identified ANKRD1 as a mesenchymal-specific transcriptional coregulator under direct androgen receptor negative control in human dermal fibroblasts and a key driver of cancer-associated fibroblasts conversion, independent of cellular senescence.

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