Publication

[Oncogenesis] Investigators showed that LUBAC increased dypoxia-inducible factor 1 (HIF1)α protein expression in cultured cells and tissues of human lung cancer and enhanced HIF1α DNA-binding and transcriptional activities, which were dependent upon LUBAC enzymatic activity.

[Journal Of Controlled Release] After loading dexamethasone, neonatal-Fc-receptor-targeted peptide (FcBP)-functionalization could effectively help nanoparticles cross the airway epithelial layer and be endocytosed by inflammatory cells, resulting in a marked decrease in inflammatory cytokines.

[American Journal Of Respiratory Cell And Molecular Biology] Using mice bearing a transgelin-Cre targeted deletion of drebrin in pulmonary fibroblasts and pericytes, scientists examined alterations in alveolar septal outgrowth, lung fibroblasts spreading and migration, and actomyosin function.

[American Journal Of Respiratory Cell And Molecular Biology] Lung epithelial fat mass and obesity-associated (FTO) knockout mice and FTO protein knockdown/overexpression A549 cell lines were constructed to evaluate the effects of FTO on acute lung injury.

[Journal Of Investigative Dermatology] Lysophosphatidylcholine acyltransferase 1 (LPCAT1) promoted keratinocyte hyperproliferation and enhanced the secretion of IL-1β, IL-6, CXCL10, CCL20, S100A9, and platelet-activating factor.

[Science Advances] In human Merkel cell carcinoma lines and clinical tumors, RT-PCR–based sequencing, immunoblotting, flow cytometry, and immunofluorescence analyses demonstrated PD-1 gene and protein expression by Merkel cell carcinoma cells.