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Extracellular Matrix News
Expression of Nephronectin in the Descemet’s Membrane of Mouse Corneas During Development and Adult Homeostasis
[Experimental Eye Research] Scientists investigated the expression of Nephronectin, an ECM protein with pleiotropic functions during organogenesis, disease, and homeostasis, during early embryonic and postnatal development, and in adult mouse corneas.
Hepatic Cell News
YTHDF2 Is a Therapeutic Target for HCC by Suppressing Immune Evasion and Angiogenesis Through ETV5/PD-L1/VEGFA Axis
[Advanced Science] Scientists discovered that trimethylated histone H3 lysine 4 and H3 lysine 27 acetylation modification in the promoter region of YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) enhanced its expression in HCC, and upregulated YTHDF2 in HCC predicted a worse prognosis.
Cell Therapy News
Immunomodulatory Performance of GMP-Compliant, Clinical-Grade Mesenchymal Stromal Cells from Four Different Sources
[Heliyon] Scientists evaluated the immunomodulatory effects of Good Manufacturing Practice (GMP)-compliant clinical grade MSCs obtained from four different sources on allogeneic peripheral blood mononuclear cells.
Cell Therapy News
ADSCs Labeled with SPIONs Tracked in Corpus Cavernosum of Rat and Miniature Pig by MR Imaging and Histological Examination
[Scientific Reports] Scientists explored the feasibility of non-invasively monitoring intracavernous injection of adipose tissue-derived stem cells in rat and miniature pig corpus cavernosum using in vivo magnetic resonance imaging.
ESC & iPSC News
ZFP281 Controls Transcriptional and Epigenetic Changes Promoting Mouse Pluripotent State Transitions via DNMT3 and TET1
[Developmental Cell] Using Zfp281 knockout mouse and degron knockin cell models, investigators identified the direct transcriptional activation of Dnmt3a/3b by ZFP281 in PSCs.
ESC & iPSC News
Characterization of Heterozygous ATTR Tyr114Cys Amyloidosis-Specific Induced Pluripotent Stem Cells
[Heliyon] Investigators took advantage of disease-specific iPS cells and generated & characterized the heterozygous ATTR Tyr114Cys amyloidosis-specific iPS cells, to determine whether Y114C iPS cells could be useful for elucidating the pathogenesis of ATTR Tyr114Cys amyloidosis.